Human erythrocyte anion permeabilities measured under conditions of net charge transfer
نویسندگان
چکیده
منابع مشابه
Chloride net efflux from intact erythrocytes under slippage conditions. Evidence for a positive charge on the anion binding/transport site
Tracer chloride and potassium net efflux from valinomycin-treated human erythrocytes were measured into media of different chloride concentrations, Clo, at 25 degrees C and pH 7.8. Net efflux was maximal [45-50 mmol (kg cell solids)-1 min-1] at Clo = 0. It decreased hyperbolically with increasing Clo to 14-16 mmol (kg cell solids)-1 min-1. Half-maximal inhibition occurred at Clo = 3 mM. In the ...
متن کاملRelationship of net chloride flow across the human erythrocyte membrane to the anion exchange mechanism
The parallel effects of the anion transport inhibitor DIDS (4,4'-diisothiocyanostilbene-2,2'-disulfonate) on net chloride flow and on chloride exchange suggest that a major portion of net chloride flow takes place through the anion exchange system. The "slippage" model postulates that the rate of net anion flow is determined by the movement of the unloaded anion transport site across the membra...
متن کاملEnhanced Charge-Transfer Kinetics by Anion Surface Modification of LiFePO4
Despite the great achievement in understanding the materials properties and powder engineering of LiFePO4, the chemical bonding at the surface has been almost ignored. Herein, we demonstrate that the undercoordinated Fe2+/Fe3+ redox couple at the surface gives a high barrier for charge transfer, but it can be stabilized by nitrogen or sulfur adsorption. The surface modification improves greatly...
متن کاملOrganic Osmolyte Permeabilities of the Malaria-induced Anion Conductances in Human Erythrocytes
Infection of human erythrocytes with the malaria parasite Plasmodium falciparum induces new permeability pathways (NPPs) in the host cell membrane. Isotopic flux measurements demonstrated that the NPP are permeable to a wide variety of molecules, thus allowing uptake of nutrients and release of waste products. Recent patch-clamp recordings demonstrated the infection-induced up-regulation of an ...
متن کاملAnion inhibitor-sensitive unidirectional sodium movements in the human erythrocyte
The increased unidirectional sodium influx found when human erythrocytes are suspended in isotonic salt solutions containing bicarbonate ions as a replacement for chloride ions was examined. The increased sodium movement appears to have the transport characteristics of anion movement. Inhibitors of anion transport such as furosemide, fluorodinitrobenzene (FDNB), and 4-acetamido-4'-isothiocyano-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1977
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1977.sp011845